WORLD CHAMPIONS
250 Rider |
| 1949 | Bruno Ruffo | Italy | Moto Guzzi |
| 1950 | Dario Ambrosini | Italy | Benelli |
| 1951 | Bruno Ruffo | Italy | Moto Guzzi |
| 1952 | Enrico Lorenzetti | Italy | NSU |
| 1953 | Werner Haas | Germany | NSU |
| 1954 | Werner Haas | Germany | NSU |
| 1955 | Herman-Peter Müller | Germany | NSU |
| 1956 | Carlo Ubbiali | Italy | MV Agusta |
| 1957 | Cecil Sandford | UK | Mondial |
| 1958 | Tarquinio Provini | Italy | MV Agusta |
| 1959 | Carlo Ubbiali | Italy | MV Agusta |
| 1960 | Carlo Ubbiali | Italy | MV Agusta |
| 1961 | Mike Hailwood | UK | Honda |
| 1962 | Jim Redman | South Rhodesia | Honda |
| 1963 | Jim Redman | South Rhodesia | Honda |
| 1964 | Phil Read | UK | Yamaha |
| 1965 | Phil Read | UK | Yamaha |
| 1966 | Mike Hailwood | UK | Honda |
| 1967 | Mike Hailwood | UK | Honda |
| 1968 | Phil Read | UK | Yamaha |
| 1969 | Kel Carruthers | Australia | Benelli |
| 1970 | Rod Gould | UK | Yamaha |
| 1971 | Phil Read | UK | Yamaha |
| 1972 | Jarno Saarinen | Finland | Yamaha |
| 1973 | Dieter Brawn | Germany | Yamaha |
| 1974 | Walter Villa | Italy | Harley-Davidson |
| 1975 | Walter Villa | Italy | Harley-Davidson |
| 1976 | Walter Villa | Italy | Harley-Davidson |
| 1977 | Mario Lega | Italy | Morbidelli |
| 1978 | Kork Ballington | South Africa | Kawasaki |
| 1979 | Kork Ballington | South Africa | Kawasaki |
| 1980 | Anton Mang | Germany | Kawasaki |
| 1981 | Anton Mang | Germany | Kawasaki |
| 1982 | Jean-Louis Tournadre | France | Yamaha |
| 1983 | Carlos Lavado | Venezuela | Yamaha |
| 1984 | Christian Sarron | France | Yamaha |
| 1985 | Freddie Spencer | USA | Honda |
| 1986 | Carlos Lavado | Venezuela | Yamaha |
| 1987 | Anton Mang | Germany | Honda |
| 1988 | Alfonso Pons | Spain | Honda |
| 1989 | Alfonso Pons | Spain | Honda |
| 1990 | John Kocinski | USA | Yamaha |
| 1991 | Luca Cadalora | Italy | Honda |
| 1992 | Luca Cadalora | Italy | Honda |
| 1993 | Tetsuya Harada | Japan | Yamaha |
| 1994 | Massimiliano Biaggi | Italy | Aprilia |
| 1995 | Massimiliano Biaggi | Italy | Aprilia |
| 1996 | Massimiliano Biaggi | Italy | Aprilia |
| 1997 | Massimiliano Biaggi | Italy | Honda |
| 1998 | Loris Capirossi | Italy | Aprilia |
| 1999 | Valentino Rossi | Italy | Aprilia |
| 2000 | Olivier Jacque | France | Yamaha |
| 2001 | Daijiro Katoh | Japan | Honda |
| 2002 | Marco Melandri | Italy | Aprilia |
| 2003 | Manuel Poggiali | San Marino | Aprilia |
| 2004 | Daniel Pedrosa | Spain | Honda |
| 2005 | Daniel Pedrosa | Spain | Honda |